EURneffy Nasal Spray - Needle-Free Adrenaline Treatment

Innovative anaphylaxis treatment now approved for UK

Following MHRA approval in July 2025, EURneffy is the UK's first needle-free alternative to adrenaline auto-injectors. Our specialist team provides comprehensive anaphylaxis management and will be ready to prescribe this innovative nasal spray treatment when it becomes available.

MHRA-approved needle-free adrenaline delivery system expected to be available for prescription in late 2025
Individual assessment required to determine suitability alongside or instead of traditional auto-injectors
Comprehensive training and support will be provided for transitioning to needle-free emergency treatment
Speak to our Team
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How EURneffy nasal spray works

EURneffy represents an important advancement in anaphylaxis treatment, delivering adrenaline (epinephrine) through a nasal spray system. Clinical evidence demonstrates this technology provides equivalent life-saving adrenaline treatment to traditional auto-injectors with improved ease of use.
The treatment works by:
Delivering precise adrenaline doses directly through the nasal passages for rapid absorption
Eliminating needle phobia and injection hesitation that can delay emergency treatment
Providing equivalent blood adrenaline levels and cardiovascular effects as auto-injectors
Offering improved stability and longer shelf life for reliable emergency protection

Clinical studies show this approach is particularly beneficial for children, needle-phobic patients, and emergency responders from the public who may hesitate with traditional injection devices.

How we approach anaphylaxis care with new treatments

We understand that living with severe allergies requires expert medical care and access to proven treatment innovations. Our approach combines specialist anaphylaxis management with preparation for evidence-based treatments like EURneffy, ensuring you receive the most effective care available.

Your treatment journey

Comprehensive assessment

Evaluate your current anaphylaxis risk and emergency action plan effectiveness

Suitability evaluation

Conduct individual assessment to determine whether EURneffy is suitable alongside or instead of traditional auto-injectors

Administration training

Provide comprehensive training on proper EURneffy administration techniques when prescribed

Emergency planning

Develop updated emergency plans incorporating the most appropriate adrenaline delivery system for your needs

The science of EURneffy nasal spray

EURneffy is a newly MHRA-approved, needle-free adrenaline (epinephrine) nasal spray for the emergency treatment of severe allergic reactions, including anaphylaxis.

It is expected to be available in late 2025 as an alternative to auto-injectors like EpiPen or Jext for suitable older children, teenagers and adults.

The spray delivers a 2mg dose of adrenaline through the nasal lining, where it’s rapidly absorbed into the bloodstream. Once active, it works to raise blood pressure, open the airways, and quickly calm the immune system’s response.

A lower-dose 1mg version, intended for younger children as an alternative to junior auto-injectors, is also in development and expected to follow.

As with all adrenaline devices, EURneffy won’t be suitable for everyone, and proper training and clinical guidance will be essential once available.

Understanding EURneffy and its benefits

Clinical evidence shows this treatment offers advantages for anaphylaxis management, providing a needle-free alternative that addresses key barriers to emergency treatment while maintaining therapeutic equivalence.
Practical advantages over auto-injectors
EURneffy’s design brings several benefits that could support better adherence and faster response in emergencies.
Simplified emergency response: Intuitive nasal spray application that reduces hesitation during critical moments
Enhanced portability: Compact, lightweight design significantly smaller than EpiPen or Jext devices
Extended shelf life: 30-month shelf life reduces replacement frequency compared to traditional auto-injectors
Better temperature tolerance: Superior stability in extreme heat and cold compared to auto-injectors
Benefits for children and schools
EURneffy effectively addresses significant challenges in paediatric anaphylaxis management
Reduced anxiety: Eliminates injection fears that can traumatise children and delay treatment
School-friendly: Teachers and staff find nasal spray administration less intimidating than injections
Enhanced safety: No risk of needlestick injuries during emergency administration
Improved emergency response: Studies show better willingness among bystanders to administer needle-free treatment
UK availability and prescription access
Following MHRA approval, EURneffy represents an important new option for anaphylaxis treatment.
MHRA approved: 2mg EURneffy device approved July 2025, with UK availability expected late September 2025
Device options: Adult-equivalent 2mg device will be available first, with a paediatric 1mg device (EpiPen Junior equivalent) in the future
Individual assessment: Specialist evaluation determines the optimal device choice for each patient
Enhanced features: Three-year shelf life and improved portability compared to traditional auto-injectors

Not sure which treatment is right? We’re here to help.

Speak to our Team

Why choose us for advanced anaphylaxis care?

Led by Professor Gideon Lack, we offer specialist expertise in anaphylaxis management and access to evidence-based treatment innovations:
World-leading specialists in severe allergies and anaphylaxis treatment
Early adoption of clinically proven treatments with comprehensive patient support
Personalised emergency action plans incorporating evidence-based treatment options
Expert medical care for transitioning between different adrenaline delivery systems
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Eczema
“As far as our family is concerned, Professor Lack is a miracle worker. We trust his advice implicitly and are very lucky to have him as our daughter’s specialist.”
Eczema
28th Sept 2024
Eczema
verified patient

Pioneering research, personalised care

Our approach combines our team's groundbreaking research into the causes and treatment of allergies with deeply personalised care. As global leaders in allergy prevention and treatment, we're dedicated to transforming lives through early intervention and innovative therapies. From food allergies and asthma to eczema and anaphylaxis, we provide evidence-based treatments tailored to each patient's needs.
More About the LACK Clinic
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Frequently asked questions

When will EURNeffy be available in the UK?
The MHRA approved the 2mg EURneffy device in July 2025, with UK availability expected by late 2025. The 2mg device is equivalent to adult EpiPen/Jext (0.3mg) for older children and adolescents. A 1mg device, equivalent to EpiPen Junior/Jext (0.15mg), will follow soon after. We're preparing to offer EURNeffy prescriptions as soon as it becomes available.
Who should consider EURneffy over traditional auto-injectors?
EURNeffy is not a simple replacement for existing EpiPen/Jext devices and requires individual assessment. It may be particularly suitable for patients who delay using adrenaline due to needle phobia, those needing improved portability and longer shelf life (3 years), or patients wanting a backup option alongside traditional auto-injectors. If you're comfortable with injectable adrenaline, traditional auto-injectors may remain your preferred choice. Our specialists provide comprehensive evaluation to determine the optimal emergency medication plan for each patient.
Who can use EURNeffy nasal spray?
EURNeffy is suitable for adults and children weighing 30kg (66 pounds) or more who are at risk of anaphylaxis. Ideal candidates include those with confirmed severe food allergies, venom allergies, or other anaphylactic triggers. A specialist medical assessment is essential to determine individual suitability and prescribe appropriate emergency medication.
How effective is EURNeffy compared to traditional auto-injectors?
Clinical studies demonstrate that EURNeffy delivers equivalent adrenaline levels in the bloodstream compared to auto-injectors, with similar cardiovascular effects crucial for treating anaphylaxis. The key advantage is improved patient acceptance and reduced administration hesitation, which can be life-saving during emergencies.
Is EURNeffy suitable for children and schools?
Yes, EURNeffy is approved for children over 30kg and offers particular advantages in paediatric care. The needle-free design reduces injection anxiety, and studies show teachers and caregivers are more comfortable administering nasal spray in emergency situations, potentially improving response times.
How do you administer EURNeffy nasal spray?
Insert the device nozzle fully into one nostril and press the plunger firmly to deliver the dose. Do not inhale during administration. A second dose may be needed using a new device in the same nostril if symptoms persist after 5-10 minutes. Emergency medical care should always be sought after any anaphylactic reaction.
How should I store EURneffy and what is its shelf life?
EURneffy has a shelf life of 30 months and does not require any special storage conditions. It can tolerate temporary excursions up to 50°C, making it practical for everyday carry in various environments without the storage concerns associated with traditional auto-injectors.
What if EURneffy gets frozen or exposed to extreme temperatures?
EURneffy remains effective even after accidental freezing below −15°C. If frozen, allow it to thaw for at least one hour before use. Freezing does not affect its shelf life. This exceptional durability in both hot and cold conditions makes EURneffy particularly reliable year-round.

Ready to learn more about advanced anaphylaxis treatment?

Our specialist team can help you understand how evidence-based innovations like Neffy might benefit your anaphylaxis management and provide expert medical care incorporating the latest advances in emergency allergy treatment. Whether you're seeking alternatives to traditional auto-injectors or want comprehensive specialist care, we're here to support you.
Speak to Our Team
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