Xolair (omalizumab) Treatment in London

Advanced biologic therapy for severe food allergies and chronic urticaria

For families living with severe food allergies or chronic urticaria, Xolair offers significant clinical advances in managing these challenging conditions. This targeted anti-IgE therapy provides baseline protection against life-threatening reactions from accidental food allergen exposure. It also delivers effective relief for chronic hives and angioedema when conventional treatments haven't provided adequate control.

Advanced food allergy protection reducing risk of severe reactions
Proven biologic therapy for chronic urticaria and angioedema
Expert administration with comprehensive monitoring in our London clinics
Speak to our Team
A girl decorating a cake

How Xolair works

Xolair is given as subcutaneous injections every 2-4 weeks in our clinic, with dosing carefully calculated based on your age, weight, and total IgE levels. The injection is administered just under the skin, similar to other routine medical injections, and typically takes only a few moments.
Your first treatment requires extended observation (up to 2 hours) to monitor for any potential allergic reactions
Subsequent appointments generally require 30 minutes of observation time to ensure you're feeling well before leaving
For food allergies, therapeutic effects typically develop over 16-20 weeks, with protection lasting for up to 12 months once treatments are stopped
For chronic urticaria, symptom improvement often begins within the first few injections, with maximum benefit usually achieved after 12-24 weeks

Our experienced nursing team ensures each injection is as comfortable as possible, and we're always available to address any questions or concerns throughout your treatment journey.

How we approach Xolair treatment

We understand the constant vigilance required when living with severe food allergies, and the impact this has on families' daily lives. Through our private clinic, we provide specialist access to Xolair for food allergy protection, building on Professor Lack's research in food allergy prevention and treatment.

Your treatment journey

Comprehensive assessment

Conduct detailed assessment including allergy testing, reaction history, and symptom severity

Dosing evaluation

Determine optimal dosing based on your age, weight and specific allergic profile

Safety monitoring

Provide expert administration with appropriate safety monitoring protocols

Specialist support

Evaluate treatment response and coordinate with your existing allergy management plan

The science of Xolair

Xolair, also known as omalizumab, is a monoclonal antibody treatment designed to help manage allergic asthma, chronic spontaneous urticaria (CSU) and, in some cases, severe food allergies. It works by targeting immunoglobulin E (IgE), the antibody responsible for triggering allergic reactions.

‍

In children and adults with allergies, IgE binds to receptors on immune cells such as mast cells and basophils, priming them to release histamine and other chemicals when exposed to an allergen. Xolair attaches to free IgE in the bloodstream, preventing it from binding to these cells. Over time, this reduces the number of IgE receptors and makes the immune system less reactive to triggers.

‍

By calming this overactive immune pathway, Xolair can reduce the frequency and severity of allergic symptoms, improve asthma control, and in urticaria, help clear hives and relieve itching. It is given as an injection under the skin, usually every 2 to 4 weeks, with dosing tailored to each patient.

Conditions treated with Xolair in our private clinic

We offer Xolair treatment for two main conditions where this innovative biologic therapy has demonstrated significant clinical effectiveness and regulatory approval.
Severe food allergy protection
Xolair provides clinically proven protection for patients with severe IgE-mediated food allergies including peanut, tree nut, egg, milk, wheat, sesame, and shellfish.
Suitable for:
Life-threatening anaphylactic reactions to trace amounts of food allergens
Multiple food allergies requiring complex avoidance strategies affecting daily life
Constant anxiety about accidental exposure at school, restaurants, or social events.
Approved for adults and children aged 1 - 65 years old
Xolair is the only proven treatment for food allergies in young adults up to the age of 17, after which age OIT is not recommended
Chronic urticaria and angioedema treatment
Xolair is approved for chronic spontaneous urticaria (chronic hives) and associated angioedema in patients over 12 years where antihistamines have proven ineffective.
Suitable for:
Persistent hives and facial swelling lasting more than 6 weeks despite maximum antihistamine doses
Unpredictable episodes of lip, eyelid, or throat swelling affecting confidence and daily activities
Sleep disruption from constant itching and discomfort
Anxiety about unpredictable symptom flares impacting work and social interactions
This targeted therapy helps control symptoms that traditional antihistamines cannot adequately manage.
Expert administration and monitoring
Xolair treatment requires specialist administration and careful monitoring to ensure optimal safety and effectiveness for both conditions.
Care includes:
Detailed assessment to determine suitability based on clinical guidelines
Expert administration with appropriate safety monitoring protocols every 2-4 weeks
Regular evaluation of treatment response and dosage adjustments as needed
Coordination with your existing allergy management plan and emergency medications
Each patient receives personalised dosing based on age, weight, and specific allergic profile in our specialist clinics.

Not sure which treatment is right? We’re here to help.

Speak to our Team

Why choose us for private Xolair treatment?

Led by Professor Lack and Dr Susan Chan, who conducted pioneering early research into Xolair as a food allergy treatment, we provide patients with expert access to advanced biologic therapies, like Xolair
Specialist expertise in food allergies and advanced biologic treatments
Clinical understanding of severe allergies and their management requirements
Careful patient selection ensuring appropriate candidates receive optimal benefit
Expert administration protocols with comprehensive safety monitoring
Private access to Xolair for food allergies when NHS treatment isn't available
Request an Appointment
A girl decorating a cake
Eczema
“As far as our family is concerned, Professor Lack is a miracle worker. We trust his advice implicitly and are very lucky to have him as our daughter’s specialist.”
Eczema
28th Sept 2024
Eczema
verified patient

Pioneering research, personalised care

Our approach combines our team's groundbreaking research into the causes and treatment of allergies with deeply personalised care. As global leaders in allergy prevention and treatment, we're dedicated to transforming lives through early intervention and innovative therapies. From food allergies and asthma to eczema and anaphylaxis, we provide evidence-based treatments tailored to each patient's needs.
More About the LACK Clinic
A girl decorating a cake

Frequently asked questions

Who is eligible for private Xolair treatment for food allergies?
Through our private clinic, Xolair for food allergies is available for patients aged 1 year and older with confirmed IgE-mediated food allergies. Ideal candidates include those with severe allergic reactions to multiple foods, frequent anaphylactic episodes despite careful avoidance, or significant symptoms impacting quality of life due to allergy severity. Assessment includes comprehensive allergy testing, detailed reaction history, and evaluation of current management strategies. Our specialists determine suitability based on clinical guidelines and individual circumstances, ensuring this advanced treatment benefits appropriate patients.
How does Xolair help with food allergies compared to carrying an EpiPen?
Xolair and EpiPens serve different but complementary roles in food allergy management. EpiPens treat allergic reactions after they occur, while Xolair provides preventative baseline protection by raising your threshold of reactivity to allergens. This means accidental exposures are less likely to cause severe reactions. However, strict allergen avoidance and carrying emergency medication remain essential - Xolair adds an extra layer of protection rather than replacing existing safety measures. This preventative approach can significantly reduce anxiety about accidental exposure.
How is Xolair administered and what should I expect?
Xolair is given as subcutaneous injections every 2-4 weeks in our clinic, with dosing determined by age, weight, and IgE levels. The first treatment requires extended observation (up to 2 hours) to monitor for any allergic reactions. For food allergies, protection typically develops over 16-20 weeks, though some patients may notice benefits earlier. We provide comprehensive guidance on maintaining allergen avoidance and emergency preparedness while receiving treatment, ensuring optimal safety and effectiveness.
What are the side effects and safety considerations with Xolair?
Xolair has a well-established safety profile when administered under specialist supervision. Common side effects include injection site reactions (redness, swelling, bruising), mild headache, and occasional flu-like symptoms. Serious allergic reactions are rare but possible, which is why treatments require careful monitoring. For food allergy patients, it's crucial to understand that Xolair doesn't cure allergies - strict avoidance and emergency medication remain essential. We provide thorough safety education and ongoing support throughout treatment.
Is Xolair more effective than oral immunotherapy (OIT) for food allergies?
Recent results from the landmark OUtMATCH study, the first head-to-head clinical trial comparing Xolair to oral immunotherapy, provide important insights. The study found that 36% of patients treated with Xolair could tolerate at least 2,000mg of peanut protein (approximately eight peanuts) and two other food allergens, compared to 19% in the oral immunotherapy group. Crucially, Xolair demonstrated a significantly better safety profile: whilst 30.5% of OIT patients experienced serious adverse events, no Xolair patients did. Additionally, 22% of OIT patients discontinued treatment due to side effects compared to none in the Xolair group, and 37.3% of OIT patients required epinephrine treatment versus only 6.9% of Xolair patients. Both treatments offer valuable benefits, and our specialists can help determine which approach may be most suitable based on your individual circumstances, treatment goals, and tolerance for potential side effects.
How effective is Xolair for food allergies and when will I see improvement?
Clinical studies show that Xolair significantly raises the threshold of allergic reactivity in most patients with food allergies. In trials, patients could tolerate substantially larger amounts of allergens than before treatment, providing important protection against accidental exposure. Most patients begin experiencing protective effects after 16-20 weeks of treatment, though some benefit may occur earlier. Regular assessment ensures optimal dosing and monitoring of treatment response. While not a cure, Xolair can significantly improve quality of life and safety for patients with severe food allergies.

Ready to explore advanced protection for severe food allergies?

If severe food allergies are limiting your family's daily life despite careful management, Xolair may provide the additional protection you require. Our specialist team can determine whether this advanced biologic therapy is appropriate for your specific allergies and guide you through every step of the private treatment process.
Speak to Our Team
A girl decorating a cake
Allergy Centre of Excellence (ACE)
10 Duchess Street
London W1G 9AB
The Portland Hospital 

215 Great Portland Street, 2nd floor
London W1W 5QT 

07493 280048 
/ 07765 977819
admin@londonallergy.com
Book Appointment
About
Prof. Gideon Lack
Dr. Susan Chan
Meet the Team
Your Visit
Testimonials
Press and Media
Fees and Insurance
FAQs
Privacy Policy
Allergy Care

Allergy symptoms
Allergic conditions
Treatments for allergies
Knowledge
Copyright 2025 London Allergy Care and Knowledge. All Rights Reserved