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MHRA Approves Neffy, a Needle-Free Anaphylaxis Treatment
Revolutionary nasal spray offers new emergency treatment option for severe allergic reactions
Living with severe allergies means always being prepared for emergencies. Today, we're pleased to share groundbreaking news that could transform how you manage anaphylaxis.
The Medicines and Healthcare products Regulatory Agency (MHRA) has approved Neffy, the UK's first needle-free adrenaline nasal spray, offering a revolutionary alternative to traditional auto-injectors.
Following approval on 18 July 2025, our specialist team at LACK Allergy Clinic is ready to help you explore whether this innovative treatment could benefit you or your child.
What this breakthrough means for families living with allergies
This approval represents hope for the estimated 1-2% of the UK population at risk of anaphylaxis. For decades, emergency adrenaline has only been available through auto-injectors like EpiPen and Jext.
While these devices save lives, we know that needle anxiety often creates barriers to using them when they're needed most.
Many patients and caregivers hesitate during emergencies due to fear of needles, uncertainty about reaction severity, or anxiety about correct administration. The large size and relatively short shelf life of traditional auto-injectors can also present practical challenges for consistent carrying and use.
Neffy addresses these concerns by eliminating the needle entirely and offering improved portability, potentially removing critical delays in life-saving treatment.
Understanding Neffy: how it compares to what you know
Neffy has been successfully used in the US since 2024 and is now available for prescription in the UK. The current 2mg dose suits adults and children weighing 30kg (approximately 4.7 stone) or more - those who would typically carry an adult EpiPen or Jext.
A 1mg version for patients under 30kg is expected soon, offering options for younger children.
Helping you make the right choice for your family
At LACK Clinic, we believe in empowering you with complete information. While Neffy offers exciting advantages, the decision isn't simply about switching devices - it's about finding what works best for your unique circumstances.
When Neffy might be ideal for you
Needle anxiety: If you or your child delays using adrenaline due to injection fears, Neffy removes this barrier entirely.
Practical advantages: Its compact size makes carrying emergency medication less burdensome, while improved temperature stability and longer shelf life offer peace of mind during travel or outdoor activities.
Caregiver confidence: Teachers, family members, or friends may feel more comfortable administering a nasal spray during emergencies.
Important considerations we'll discuss with you
Building real-world evidence:
- Auto-injectors have decades of proven effectiveness in real-life situations.
- Neffy's approval is based on detailed pharmacological studies in healthy adults and children, which confirmed that adrenaline uptake and vital sign changes are at least equivalent to auto-injectors.
- Some studies included self-drawn adrenaline syringes in their design, while these are effective and routinely used in medical settings worldwide, they're not practical for community use.
- As with any new medical device, it will take time to build the same depth of real-world experience.
Familiarity factors:
- Most caregivers, school staff, and first aiders are trained on auto-injectors.
- Transitioning to Neffy means ensuring everyone in your support network understands the new device.
- Educational videos for Neffy are currently in development and will be made available as soon as possible.
Comfort with current treatment:
- If you're confident using your current auto-injector, it remains an excellent, life-saving choice.
Realistic adoption timeline:
- Making changes to established allergy practice can prove difficult and take time, so we expect that it will be a while until Neffy is properly adopted and its exact place in management pathways, alongside traditional auto-injectors, becomes clear.
- Think of this decision like choosing the right tool for an important job - both options are effective, but one might suit your specific needs better.
Simple steps to use Neffy
The device is designed for straightforward emergency use. You'll insert the nozzle fully into one nostril and press the plunger firmly to deliver the complete dose. The spray works even if your nose feels blocked from allergies or a cold.
As with all adrenaline devices, you should always carry two Neffy devices. If symptoms haven't clearly improved within five minutes of the first dose, use the second device immediately.
Comprehensive training videos and instructions are available at neffy.com/how-to-use, and our team will ensure you feel completely confident using any device we prescribe.
How we can guide you through this decision
Making changes to your allergy management plan requires expert support, and our team is here to help. Led by Professor Gideon Lack, whose groundbreaking research has transformed allergy care worldwide, we're committed to finding the best solution for your family.
The decision as to which devices will be best for you or your child is individual, depending on multiple factors, and a conversation to consider the risks and benefits is necessary. You'll also need training on how to use any new device, plus an updated allergy action plan reflecting your choice.
Ready to explore your options?
Whether you're curious about Neffy or want to review your current allergy management plan, our team is here to support you.
We understand that managing severe allergies affects your entire family, and we're committed to helping you feel confident and prepared.
If you have any questions or would like to discuss Neffy, please get in touch with our team:
- Email: admin@londonallergy.com
- Phone: 07493280048 or 07765977819
Taking control of your allergy management starts with expert guidance. Let us help you navigate this exciting new option and ensure you have the most appropriate emergency treatment for your needs.
This information is for guidance only. Always follow your allergy specialist's advice regarding emergency medications and treatment plans. Emergency services should be called immediately for any severe allergic reaction, regardless of which adrenaline device you use.
Helping you make the right choice for your family
At LACK Clinic, we believe in empowering you with complete information. While Neffy offers exciting advantages, the decision isn't simply about switching devices - it's about finding what works best for your unique circumstances.
When Neffy might be ideal for you
Needle anxiety: If you or your child delays using adrenaline due to injection fears, Neffy removes this barrier entirely.
Practical advantages: Its compact size makes carrying emergency medication less burdensome, while improved temperature stability and longer shelf life offer peace of mind during travel or outdoor activities.
Caregiver confidence: Teachers, family members, or friends may feel more comfortable administering a nasal spray during emergencies.
Important considerations we'll discuss with you
Building real-world evidence:
- Auto-injectors have decades of proven effectiveness in real-life situations.
- Neffy's approval is based on detailed pharmacological studies in healthy adults and children, which confirmed that adrenaline uptake and vital sign changes are at least equivalent to auto-injectors.
- Some studies included self-drawn adrenaline syringes in their design, while these are effective and routinely used in medical settings worldwide, they're not practical for community use.
- As with any new medical device, it will take time to build the same depth of real-world experience.
Familiarity factors:
- Most caregivers, school staff, and first aiders are trained on auto-injectors.
- Transitioning to Neffy means ensuring everyone in your support network understands the new device.
- Educational videos for Neffy are currently in development and will be made available as soon as possible.
Comfort with current treatment:
- If you're confident using your current auto-injector, it remains an excellent, life-saving choice.
Realistic adoption timeline:
- Making changes to established allergy practice can prove difficult and take time, so we expect that it will be a while until Neffy is properly adopted and its exact place in management pathways, alongside traditional auto-injectors, becomes clear.
- Think of this decision like choosing the right tool for an important job - both options are effective, but one might suit your specific needs better.
Simple steps to use Neffy
The device is designed for straightforward emergency use. You'll insert the nozzle fully into one nostril and press the plunger firmly to deliver the complete dose. The spray works even if your nose feels blocked from allergies or a cold.
As with all adrenaline devices, you should always carry two Neffy devices. If symptoms haven't clearly improved within five minutes of the first dose, use the second device immediately.
Comprehensive training videos and instructions are available at neffy.com/how-to-use, and our team will ensure you feel completely confident using any device we prescribe.
How we can guide you through this decision
Making changes to your allergy management plan requires expert support, and our team is here to help. Led by Professor Gideon Lack, whose groundbreaking research has transformed allergy care worldwide, we're committed to finding the best solution for your family.
The decision as to which devices will be best for you or your child is individual, depending on multiple factors, and a conversation to consider the risks and benefits is necessary. You'll also need training on how to use any new device, plus an updated allergy action plan reflecting your choice.
Ready to explore your options?
Whether you're curious about Neffy or want to review your current allergy management plan, our team is here to support you.
We understand that managing severe allergies affects your entire family, and we're committed to helping you feel confident and prepared.
If you have any questions or would like to discuss Neffy, please get in touch with our team:
- Email: admin@londonallergy.com
- Phone: 07493280048 or 07765977819
Taking control of your allergy management starts with expert guidance. Let us help you navigate this exciting new option and ensure you have the most appropriate emergency treatment for your needs.
This information is for guidance only. Always follow your allergy specialist's advice regarding emergency medications and treatment plans. Emergency services should be called immediately for any severe allergic reaction, regardless of which adrenaline device you use.
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